VEGF与PCNA在翼状胬肉中的表达

Expression of VEGF and PCNA in pterygium

目的探讨VEGF与PCNA在翼状胬肉中的表达。方法应用免疫组化法检测30例翼状胬肉组织和30例正常结膜中VEGF与PCNA的表达。结果 30例翼状胬肉中VEGF和PCNA的阳性表达IHS分别为4.70±1.74,6.23±1.43;30例正常结膜中VEGF和PCNA的阳性表达IHS分别为1.90±0.71,2.13±0.82。VEGF、PCNA阳性表达在翼状胬肉与正常结膜两组间差异有统计学意义(P<0.01)。结论 VEGF、PCNA在翼状胬肉中的高表达,提示翼状胬肉组织血管活性、增殖活性增强。

OBJECTIVE To investigate the role of vascularendothelial growth factor（VEGF）and Proliferating Cell Nuclear Antigen（PCNA）in the occurrence and development of human pterygium. METHODS The immunohis-tochemical method was used to examine the expressions of VEGF and PCNA in 30 cases of pterygium and 30 cases with normal conjunctiva. RESULTS VEGF and PCNA were positively expressed in pterygium and normal conjunctiva. The positive expressions（IHS） of VEGF and PCNA in pterygium were 4.70±1.74 and 6.23±1.43;and in normal conjunctiva were 1.90±0.71 and 2.13±0.82. The expressions of VEGF and PCNA between the pterygium and normal conjunctiva were statistically significant（P0.01）. CONCLUSIONS These data demonstrated that VEGF and PC-NA may play an important role in the incidence and development of pterygium.