正常眼压性青光眼患者外周血中IL-6和IL-12含量研究的意义

Significance of peripheral blood levels of IL-6 and IL-12 in patients with normal tension glaucoma

目的:分析正常眼压性青光眼患者外周血中白细胞介素-6(IL-6)、白细胞介素-12(IL-12)与白内障对照组测量值上有无差异,从而探讨免疫因素在正常眼压性青光眼发病机制中的意义。方法:正常眼压性青光眼患者37例,白内障对照组40例。两组年龄、性别无显著性差异。分别抽取外周血3mL,采取双抗体夹心酶联免疫吸附法(ABC-ELISA)方法分别测量IL-6,IL-12含量。结果:正常眼压性青光眼组IL-6,IL-12含量分别为(1.402±2.297)pg/mL和(12.475±3.973)pg/mL;白内障对照组含量分别为(8.214±5.355)pg/mL和(20.116±4.216)pg/mL。两组差异均有统计学意义(P<0.05)。结论:正常眼压性青光眼患者外周血中IL-6,IL-12含量低于白内障对照组,提示免疫因素可能在正常眼压性青光眼发病机制中起着重要的作用。

AIM： To assess the role of the immune system in the pathophysiology of normal tension glaucoma （NTG） by analyzing the level difference of the cytokine interleukin-6 （IL-6） and IL-12 in peripheral blood between patients with NTG and cataract.·METHODS： The concentrations of IL-6, IL-12 were assessed in 37 cases of NTG patients, 40 cases of cataract patients by Enzyme-Linked immunosorbent assay, 3mL peripheral blood was extracted separately to do the test. No significant differences existed in age or gender between the two groups.·RESULTS：IL-6, IL-12 concentrations in NTG group and cataract group were （1.402±2.297）pg/mL, （8.214±5.355）pg/mL and （12.475±3.973） pg/mL, （20.116±4.216） pg/mL respectively. The mean concentrations of IL-6 and IL-12 in NTG group were significantly lower than these in cataract group （P0.05）.·CONCLUSION： The levels of IL-6, IL-12 in peripheral blood of patients with NTG were lower than those of cataract group. The alteration of the cellular immune system in patients with NTG supports our hypothesis that the immune system may play an important role in the initiation and sustainment of glaucomatous optic neuropathy.