经皮消融配合三维适形放疗治疗原发性肝癌的疗效分析

Analysis of three dimensional conformal radiationtherapy with percutaneors ablation for primary hepatic carcinome

目的:观察经皮消融配合三维适形放疗治疗原发性肝癌的疗效。方法:45例原发性肝癌随机分成综合组和对照组。综合组21例,采用经皮消融三维适形放疗,对照组单用经皮消融。结果:综合组的局控率为85.7%,而对照组为58.3%,两者有显著性差异。1,2,3年的生存率综合组和对照组分别是81%,62.5%,25%;71.8%,33%,8%。两者差异有统计学意义。结论:原发性肝癌三维适形放疗结合经皮消融疗效较好。

Objective：To evaluate the effect of three dimensional conformal radiation（3DCRT） with percutaneous ablation（PA） for unresectable primary hepatic carcinoma. Methods ：Total of 45 patients with primary hepatic carcinoma were randomized to 2 groups： 21 patients were treated with 3DCRT plus PA and the rest （control） were treated with PA only. For 3DCRT, radiation was given by 8MV -x- ray,patients received a total dose of 40 -50Gy, 5Gy per session every other day. Results：the 1,2,3 year survival rates of 3DCRT plus PA group and control group were 81% ,62.5% ,25% ;71.8% ,33% ,8%. The difference between the two groups was significant. The response rate （ CR ＋ PR） of 3DCRT plus PA and PA alone group were 85.7% and 58.3%. The difference was statistically significant. Conclusion：three dimensional conformal radiotherapy combined with PA is effective for unresectable primary liver cancer.