摘要
目的:探讨Ezrin在宫颈癌中的表达及与临床参数的关系。方法:收集50例宫颈癌组织及50例相应癌旁正常宫颈组织,采用RT-PCR方法检测Ezrin的表达。结果:RT-PCR显示,在宫颈癌组织及癌旁正常宫颈组织中均可检测到Ezrin mRNA表达,宫颈癌组织表达水平显著高于癌旁正常组织,两者相比差异有统计学意义(P<0.01)。Ezrin mRNA表达随着淋巴结转移、细胞分级的提高和浸润深度的增强,但均无统计学意义(P>0.05)。结论:Ezrin可能在宫颈癌发病中起了重要作用,但Ezrin mRNA与宫颈癌浸润转移关系尚不明确。
Objective：To study the expression of ezrin in cervical cancer tissues and its adjacent normal tissues and its relationship to clinical parameters. Methods ： Fifty cervical cancer tissue samples and adjacent normal tissues were collected method to detect mRNA level of ezrin by RT- PCR. Results ：The expression of ezrin was up -regula- ted in cervical cell carcinoma tissue as compared with adjacent normal tissue （ P 〈 0.01 ）. Ezrin mRNA expression was not associated with histopathologic grade, the depth of cancer infiltration and lymph node metastasis （ P 〉 0.05 ）. Conclusion：ezrin mayrplay important role in cervical cancer development, but the relation between ezrin mRNA and cervical cancer has not been known.
出处
《现代肿瘤医学》
CAS
2010年第6期1215-1217,共3页
Journal of Modern Oncology
关键词
宫颈癌
埃兹蛋白
肿瘤转移
肿瘤侵润
cervical cancer
ezrin protein
cancer metastasis
cancer infiltration
