狼疮合并可逆性后部白质脑病综合征的病因分析

Analysis of risk factors for reversible posterior leukoencephalopathy syndrome in lupus

目的 分析系统性红斑狼疮（SLE）合并可逆性后部白质脑病综合征（RPLS）的不同病因.方法 观察2例SLE合并RPIS患者的临床表现和影像学资料.系统地回顾了文献报道33例患者的临床表现.分析全部35例患者引起SLE合并RPLS的病因.结果 35例SLE合并RPL患者中32例有高血压;3例SLE合并RPLS患者无高血压;1例明确与利妥昔单抗相关,1例明确与环孢素治疗相关.结论 引起SLE合并RPLS的原因有不同原因引起的高血压、SLE神经系统受累、药物的神经毒性等因素.

Objective To analyze the different risk factors for reversible posterior leukoencephalopathy syndrome （ RPLS） in systemic lupus erythematosus （SLE）. Methods The clinical and imaging characteristics of 2 cases were described in details. The literature reports for 33 cases of SLE and RPLS were reviewed systematically. The etiologies of SLE and RPLS were analyzed for all 35 cases. Results Thirty-five cases of SLE patients were complicated with RPLS, 32 cases suffered hypertension, 3 cases had no hypertension, 1 case was explicitly related with rituximab and 1 case was related with cyclosporine therapy. Conclusion SLE complicated by RPLS has different causes, such as hypertension, SLE involving central nervous system and drug neurotoxicity.