阿托伐他汀治疗脑梗死患者颈动脉斑块的效果与年龄关系探讨

Study on the relationship between the treatment of atorvastatin on carotid artery atherosclerosis and age in patients with cerebral infarction

目的观察阿托伐他汀治疗脑梗死(CI)患者颈动脉斑块的效果及与年龄关系。方法将103例存在颈动脉斑块的脑梗死患者随机分为两组。干预组口服阿托伐他汀及阿司匹林肠溶片,对照组仅口服阿司匹林肠溶片;比较治疗前后效果及与年龄关系。结果用药前中年患者的颈动脉不稳定斑块率高于老年患者(P<0.05);干预组治疗6个月后斑块积分差值和改善百分比与对照组比较有显著性差异(P<0.01);干预组不稳定斑块率自身前后比较及与对照组比较均有显著性差异(P<0.01);斑块积分改善百分比与年龄呈负相关(P<0.01)。结论阿托伐他汀治疗CI患者颈动脉斑块的效果明确并与年龄呈负相关。

Objective To Investigate the treatment of atorvastatin on carotid artery atherosclerosis（CAA）and the influence of age in patients with cerebral infarction.Methods 103 patients with CI and CAA were randomly divided into two groups：Investigation group and control group.Investigation group received atorvastatin and enteric coated-ASA,while the control group received enteric coated-ASA only.Compared the effect after treatment and the relation with age.Results Compared with control group,after 6 months of treatment,the size of CAA and the rate of vulnerable plaque of carotid reduced in the investigation group（P0.01）.Young people were improved better than old man（P0.01）.Conclusion It is shown that atorvastatin can effectively stabilize and reduce CAA.Moreover,the effect and age have negative correlation.