冠状动脉支架材料与炎症反应

Coronary stent material and inflammatory reaction

目的:评价心血管支架材料与炎症反应的关系。方法:以"冠状动脉疾病,冠状动脉支架置入,炎症介导,支架材料"为检索词,在中国期刊文数据库(CNKI:2005/2009)及Medline数据库(Pubmed:1995/2008)中采用电子检索方式进行文献初检,排除综述类文献,共检索到45篇文献,由作者按纳入标准筛选后,共纳入32篇文章进一步分析总结。结果:雷帕霉素药物涂层支架生物相容性良好,再狭窄发生率低,是较理想的心血管支架材料。有关心血管支架材料生物相容性的临床应用显示,药物涂层支架在临床应用中无年龄、性别和病变部位的影响,从评估标准上可以证实涂层支架可降低支架置入后的炎症反应及再狭窄发生率,在降低心血管事件发生方面也具有优势。结论:除了抗增殖的特性,与金属裸支架相比,药物涂层支架的抗炎特性显著,可通过其抗炎作用降低再狭窄发生率。雷帕霉素药物涂层支架是一种良好的心血管支架材料。

OBJECTIVE：To evaluate the correlation of cardiovascular stent material with the inflammatory response.METHODS：Using ＂coronary artery disease,coronary stent implantation,inflammation mediation,scaffold＂ in Chinese for the search terms,the Chinese Journal Full-text databases（CNKI：2005/2009） and the Medline database（Pubmed：1995/2008） were retrieved by computer.After excluding review articles,totally 45 articles were retrieved.According to the inclusion criteria,32 articles selected by the author were involved in further analysis.RESULTS：Rapamycin-eluting stents have excellent biocompatibility and low incidence of restenosis.It is an ideal material for cardiovascular stents.The clinical application of cardiovascular stent biocompatibility showed that drug-eluting stents in clinical application are not affected by age,sex and lesion site.Coated stents can be confirmed to reduce the inflammatory response and the incidence of restenosis after stent implantation,and have an advantage in reducing adverse cardiac events.CONCLUSION：In addition to anti-proliferative properties,as compared with bare metal stents,drug-eluting stents have significant anti-inflammatory properties and then reduces the incidence of restenosis.Rapamycin-eluting stents is a good cardiovascular scaffold.