楔形平板流动腔测量细胞硬度的数值模拟研究

Numerical Simulation Study on the Cell Stiffness Detected by Wedge-shaped Flow Chamber

细胞硬度或形变能力的测量对深入研究细胞的生物学功能及甄别细胞产生病变有着重要意义。以楔形平板流动腔作为细胞形变的加载装置,通过分析细胞在楔形平板流动腔中的运动情况,建立数学模型,通过数值模拟方法研究细胞形变系数与细胞在楔形平板流动腔内移动速度的关系,并以此测量细胞硬度或形变能力。结果表明,细胞在楔形平板流动腔内不同观测点的细胞移动速度可以作为细胞形变能力的测量依据。

The detection of cell stiffness is very important in investigating the biological function of cells and screening pathological changes of cells.In this paper,we focused on setting up mathematic model for cell movement for analyzing the cell deformation in a wedge-shaped flow chamber.The deformation of a cell in wedge-shaped flow chamber was studied with simulation based on the speed of liquid flow and some parameters of chamber.The cell speed at the location in flow chamber could be used to measure the deformability of cells.The results showed that wedge-shaped flow chamber could provide a potential method to measure the stiffness of cells.