^(18)F-FDG PET/CT SUVmax与淋巴瘤临床分期、病理分级关系的探讨

Analysis of standard uptake values of ^(18)F-FDG PET/CT in relation to clinical staging,pathological classification of lymphoma

目的:探讨18F-脱氧葡萄糖(18F-FDG)PET/CTSUVmax与淋巴瘤临床分期、病理分级关系。方法:初治淋巴瘤患者23例(均经病理组织学确定),按Ann Arbor分期法进行临床分期,Ⅰ、Ⅱ、Ⅲ及Ⅳ期患者分别有5、6、7、5例;其中20例NHL患者,以病理结果为依据,低、中、高度恶性患者分别有2、9、9例。所有患者皆行18F-FDG PET/CT显像,获得所有病灶的SUVmax值,采用方差分析进行数据处理。结果:①Ⅰ、Ⅱ、Ⅲ、Ⅳ期患者的淋巴结平均SUVmax值分别为6.00±2.69、6.88±4.08、11.10±5.05和10.46±4.48,Ⅱ期与Ⅲ、Ⅳ期之间的差异显著(P=0.000),其余各期之间无统计学差异;②低、中、高度恶性NHL患者病灶的平均SUVmax值分别为5.13±0.15、8.47±5.24、10.53±5.37,后两者之间有差异(P=0.03)。结论:SUVmax值与淋巴瘤临床分期及NHL恶性程度呈正相关趋势。

Objective：To explore the relations of the SUVmax of 18 F-fluorodexyglucose（18F-FDG） PET/CT and the clinical staging,pathological classification of lymphoma.Methods：Whole body 18 F-FDG PET/CT was performed in 23 patients with pathologically confirmed lymphoma,who received no previous treatment.By Ann Arbor staging method,there were 5,6,7 and 5 cases for stage Ⅰ,Ⅱ,Ⅲ and Ⅳ separately.By histopathology,there were 20 NHL including 2 low,9 medium and 9 high malignant patients.The SUVmax of all lesions was calculated,which were treatmented by one-way ANOVA test.Results： ① The average SUVmax of lymphnode in stageⅠ,Ⅱ,Ⅲ and Ⅳ patients were 6.00±2.69,6.88±4.08,11.10±5.05 and 10.46±4.48 respectively,showing significant differences between Ⅱ and Ⅲ,Ⅳ（P=0.000） but no differences between other stagings by statistics;② The average SUVmax of lymphoma lesions in low,medium and high malignant patients were 5.13±0.15,8.47±5.24 and 10.53±5.37 respectively,showing significant difference between the latter two but no differences between the others by statistics.Conclusion：The SUVmax had positive correlation tendencies with the lymphoma staging and the pathological classification of NHL.