肠道通透性改变对肝移植感染影响研究

Effects of the intestinal mucosa permeability changes on the infection in liver transplantation

目的:探讨肝移植术后感染与肠黏膜通透性的关系。方法:回顾性分析肝移植术后感染与未感染者血清二胺氧化酶、D-乳酸、内毒素的水平及其与感染的相关性,观察感染者肠黏膜形态学变化。结果:肝移植感染者血清二胺氧化酶、D-乳酸、内毒素水平升高与感染呈正相关(P<0.05);感染者肠黏膜萎缩,炎症细胞浸润。结论:肝移植感染与术前肠黏膜通透性改变有关。

Objective To explore the relationship between the intestinal mucosa permeability changes and the infection in liver transplantation.Methods The levels of serum diamine oxidase,D-lactate,endotoxin and their relationship with the infection in liver transplantation were evaluated,and the morphological changes of the infectious intestinal mucosa were studied microscopically.Results The increased serum levels of diamine oxidase,D-lactate and endotoxin in infection were positively correlated to the infection in liver transplantation（P〈0.05）.Morphologically,the infectious intestinal mucosa represented atrophy shrink and inflammatory cell infiltration.Conclusion The infection in liver transplantation is correlated to the high permeability of the intestinal mucosa.