射频消融早期抑制兔肝VX2肿瘤细胞增殖实验研究

Inhibitory action to proliferation of the rabbit's hepatic VX2 carcinoma in the early stage of radiofrequency ablation

目的:观察射频消融早期对兔肝VX2肿瘤细胞增殖的影响。方法:将试验兔分为2组:A组(对照组)不行射频消融治疗;B组(射频消融组、残瘤组),观察射频消融后不同时期的病理表现及肺转移情况。结果:射频消融后2,7d,B组增殖细胞核抗原指数明显低于同期A组,2组比较差异有统计学意义(P<0.05)。射频消融后14 d B组增殖细胞核抗原指数较前增加,但与A组比较差异无统计学意义(P>0.05)。射频消融后2,14 d,2组肺转移率差异无统计学意义(P>0.05)。射频消融后7 d,2组肺转移率差异有统计学意义(P<0.05)。结论:射频消融早期对残余肿瘤细胞增殖及肺转移有抑制作用。

Objective To observe the effect of radiofrequency ablation on the cell proliferation in rabbit＇s hepatic VX2 carcinoma in the early stage.Methods The rabbits were randomly divided into 2 groups： group A（control group） and group B（RFA group and residual tumor group）,and were observed the pathological changes and lung metastasis in different stage after radiofrequency ablation.Results The proliferating cell nuclear antigen indexes on the 2nd and 7th day in group B were obviously lower than those in group A,which showed a significant difference between two groups.The proliferating cell nuclear antigen index on the 14th day in group B had no significant difference with that in group A.There was no significant difference in pulmonary metastasis rate between two groups on the 2nd and 14th day but not on the 7th day.Conclusion Radiofrequency ablation has the inhibitory action to the proliferation of residual tumor and pulmonary metastasis in the early stage.