红霉素在小儿哮喘急性发作中的应用

The erythromycin in young child asthma ute attack application

目的：观察红霉素治疗小儿哮喘急性发作的疗效。方法：选择2004年10月2006年12月在湖南省儿童医院呼吸免疫科住院确诊的哮喘急性发作患儿80例，随机分为两组，两组病例均给予青霉素抗感染、静脉琥珀酸氢化考的松、氨荼碱，雾化吸入万托林、吸氧、翻身拍背吸痰等对症支持治疗。治疗组40例在常规治疗基础上加用红霉素100mg／（kg．次）加入葡萄糖液中静脉滴入，0．1％，每日2次，连用3天。结果：治疗组在缓解喘息症状、缩短哮呜音持续时间、缩短住院时间方面均明显优于对照组。结论：哮喘急性发作是儿科急症之一，快速缓解哮喘急性发作是成功的关键。红霉素具有一定的抗气道非特异性炎症作用，还可抑制黏液分泌，抑制茶碱清除率，延长类固醇排泄时间，刺激肾上腺素的分泌等可协同其他药物快速缓解哮喘急性发作。

Objective： Observes the erythromycin to treat the young child asthma ute attack the curative effect. Methods：Chose in October, 2004 in December, 2006 in the Hunan Province Pediatric hospital breath immunity branch in hospital diagnosis asthma ute attack baby 80 examples, divided into two groups stochastically, two groups of cases gave the pine which, the ammonia bitter edible plant alkali the penicillin anti--infection, the vein succinic acid hydrogenation tested, the atomization inhale ten thousand Tolin, the oxygen uptake, the turning over to pat the back to attract the phlegm and so on just right for the itlness support treatment. The treatment group 40 examples add in the conventional treatment foundation with erythromycin 100mg/（the kg. time） join the glucose fluid median vein to drip into, 0.1%, daily 2 times, is used together for 3 days. Results：Treats the group in the alleviation respite symptom, the reduction heavy breathing to call the sound duration, the reduction in hospital time aspect obviously to surpass the control group. Conclusion：The asthma ute attack is one of department of pediatrics acute diseases, alleviates the asthtna ute attack is the successful key fast. The erythromycin has certain anti--gas channel non--specificity inflammation function, but may also suppress the mucus secretion, suppresses the theine percentage clearance, the extension steroid excretion time, the stimulation adrenalin secretion and so on may coordinate the other medicine fast alleviation asthma ute attack.