增强型体外反搏对冠心病患者血清血管内皮生长因子的影响——附31例检测分析

The effect of enhanced extracorporal counterpulsation on serum vascular endothelial growth factor in patients with coronary heart disease.

目的：探讨增强型体外反搏对冠心病患者血清血管内皮生长因子（ＶＥＧＦ）的影响。方法：采用酶联免疫吸附测定法检测３１例冠心病患者和３４名正常人血清中ＶＥＧＦ水平，并观察冠心病患者在增强型体外反搏治疗过程中及反搏后血清ＶＥＧＦ的动态变化。结果：治疗前，冠心病患者血清ＶＥＧＦ含量（２７２±１４２）ｎｇ／Ｌ明显高于正常人（１２２±３０）ｎｇ／Ｌ，Ｐ＜０．００１。在体外反搏治疗第一疗程末患者血中ＶＥＧＦ水平明显降低，但在随后的两个疗程中ＶＥＧＦ又有一定程度的增高，但仍低于反搏前水平。结论：本研究从ＶＥＧＦ的角度发现体外反搏可改善冠心病患者的心肌缺血。

Objective:To investigate the effect of enhanced extracorporal counterpulsation(EECP)on serum vascular endothelial growth factor(VEGF)in patients with coronary heart disease(CHD) Methods:The serum VEGF levels of 31 CHD patients and 34 cases of control were determined by enzyme linked immunosorbent assay Before,during and after EECP treatment Results:The serum VEGF levels in patients with CHD were much higher than that in control subjects(272±142 vs 122±30 ng/L, P <0 001).The serum VEGF levels of CHD patients decreased remarkably after 1 course of EECP treatment.However the concentrations of VEGF increased slightly after 2～3 courses of treatment.Conclusion:The results suggest that EECP treatment may improve myocardial perfusion in patients with CHD,and may also exert an effect on serum VEGF level.