摘要
为探讨炎性细胞因子在肺缺血再灌注损伤发病机制中的作用,采用大鼠在体温缺血再灌注模型,动态测定了肺组织和血浆肿瘤坏死因子α(TNF_α)、白介素-6(IL-6)和白介素-8(IL-8)含量的变化。结果表明,肺缺血再灌注损伤早期肺组织TNF_α、IL-6、IL-8相继释放增加,上述因子的血浆变化滞后于肺组织变化。提示炎性细胞因子参与了肺缺血再灌注损伤的发生和发展过程。
To investigate the role of inflammatory cytokines in the pathogenesis of lung ischemia-reperfusion injury , the rat ischemia model with occlusion of left hilus for 45-minute was set up and the changes of levels of TNF_α,IL-6 and IL-8 in lung tissues and plasma were dynamically observed during lung ischenia-reperfusion. The results showed that the releases of TNF_α,IL-6 and IL-8 in lung tissues were successively increased in the early stage of lung damage and the alterations of above-mentioned cytokines in plasma lagged those in lung tissues. It is concluded that inflammatory cytokines could participated in the onset and development of lung ischemia-reperfusion injury.
出处
《重庆医学》
CAS
CSCD
1999年第1期5-6,共2页
Chongqing medicine