自身胆汁以不同压力和时间灌注犬胰管对血清溶菌酶和补体活性的影响

The effects of autobile perfusing pancreatic duet of dog with different pressures and time on serum lysozyme and complement activies

为探讨血清溶菌酶，补体活性与急性胰腺炎病变程度的关系，本实验以３０只健康成年犬为动物模型，采用 自身胆汁以不同压力和持续时间灌注犬胰管，观察由此所造成的急性胰腺炎在严重程度上有何不同。结果显示：水肿性 与坏死性组于灌注后２４ｈ起血清溶菌酶与对照比较明显升高（Ｐ＜０．０１），坏死性组总补体活性与对照和水肿性比较则 明显下降（Ｐ＜０．０１），提示血清溶菌酶，补体活性在急性胰腺炎的发病机理中具有一定的作用。

This study was to observe the relationship of serum lysozyme and complement activities with severify of acute pancreatitis. 30 healthy adult dogs were used as experimental animals. The seventy of acute pancreatits caused by autobile perfusing pancreatic duct of dog with different pressure and time was studied. The results showed that serum lysozyme of edematous group and necrotic group raised at 24 hour after perfusion compared with conrtol group(P < 0. 01),but the complement activity in necrotic group was lower than that in conrtol group and edematous group (P < 0.01 ). It is suggessted that serum lysozyme and complement avtivities play a significant role in the pathogenesis of acute pancreatitis.