人肝癌中P16蛋白的表达缺失与意义

Clinical Significance of Loss of P16 Expression in Human Primary Hepatocellura Carcinoma

用免疫组化法对３５例手术切除的原发性肝细胞性肝癌（ＨＣＣ）标本中Ｐ１６蛋白的表达作了检测，结果发现１５例（４５． ７％）Ｐ１６蛋白表达阴性。分化低癌组织 Ｐ１６蛋白缺失率显著高于分化高者（ Ｐ＜０．０１），且 Ｐ１６表达缺失的患者生存期明显短于有 Ｐ１６表达者（ Ｐ＜０． ０５），提示 Ｐ１６蛋白表达的缺失可能与 ＨＣＣ的发生、发展及预后有关。

p16 expression was determined by immunohistochemical analysis on 35 paraffin specimens of primary hepatocellular carcinoma(HCC)that were curatively resected. Fifteen of 35 HCC specimen specimens (45. 7 % )showed negative p16 expression. The rate of negative p16 expression was significantly higher in the poor differentiated HCC than in the differentiated HCC(P <0. 01 ). Morever,patients with negative p16 epression survived for a significantly shorter period of time than those with positive p16 expression(P >0. 05). The results suggest that loss of p16 expression may be relevant to the development and prognosis of hepatocellular carcinoma.