前白蛋白在病毒性肝炎检测中的意义

Clinical Significance of Assaying Serum Prealbumin in the Patients with Viral Hepatitis

目的探讨前白蛋白在病毒性肝炎患者中检测的意义。方法对172例各型病毒性肝炎患者及41例健康体检对照组进行血清前白蛋白（S－pA）的比较检测。结果发现各型肝炎在急性期（或活动期）S－pA水平与对照组相比均有下降，且病情越重．S－pA水平下降越明显，其中以重症肝炎S－pA水平下降最为明显；随病情好转，S－pA逐渐上升。结论S－pA水平是反映肝功能急性损害与肝功能恢复的一项灵敏指标；在肝硬变患者S－pA可反映肝脏最大储备功能；在重症肝炎，通过对S－pA的动态观察，可判断其预后。

Objective To research into the significance of prealbumin detection in patients with varied viral hepatitis. Methods We assayed the serum prealbumin (S - pA) in 172 patients with varied viral hepatitis and 41 normal persons as the control group. Results S -pA levels were decreased in the acute period or active period of the patients with varied viral hepatitis, compared with the control group. The more severe the patients were, the more significant decrease of the S -pA levels were. The most significant decrease of S -pA level appeared in the patients with severe hepatitis. As the improvement of diseases,the S -pA levels were gradually increased. Conclusion The S - pA level is a sensitive parameter which reflects the damage and the recovery of liver function in the varied viral hepatitis. The S - pA level may reflects the maximum reserve function in the patients with cirrhosis. The dynamical observation of S -pA level may be used to estimate the prognosis of patients with severe hepatitis.