干细胞治疗神经性勃起功能障碍的研究现状

Advance of Neurogenic Erectile Dysfunction Therapy by Stem Cells

神经性勃起功能障碍(neurogenic erectile dysfunction,NED)的发生与勃起功能相关神经的损伤密切相关。最近,干细胞对阴茎勃起神经的修复和保护作用的临床前研究已经成为热点。本文综述了神经源性胚胎干细胞(NESCs)、肌源性干细胞(MDSCs)、脂肪源性干细胞(ASCs)和间充质干细胞(MSCs)等在NED方面的研究进展。早期研究显示干细胞或基因修饰的干细胞对ED治疗持久有效,并可能成功治愈ED。干细胞有望应用于NED的临床治疗。干细胞作为新的治疗方法应用于临床后,将会对法医临床学鉴定提出新的挑战。

Neurogenic erectile dysfunction（NED） commonly results from erectile nerve damage.Recent researches have focused on the preclinical study of stem cell-based therapies targeted at repairing and protecting nervi erigentes.In this paper,researches of NESCs,MDSCs,ASCs and MSCs in NED are reviewed.Early studies have demonstrated that stem cells and gene modified stem cells were effective to the therapy of ED,even likely to cure ED.Stem cells are expected to be applied in the clinical therapy of NED.Stem cells as a new therapy technique will bring up a new challenge in forensic clinical medicine.