乙型肝炎患者HBeAg水平与HBV-DNA含量相关性

Correlations between the level of HBeAg and HBV-DNA in patients with Hepatitis B

目的对HBeAg阳性或阴性者与HBV-DNA含量的检测结果进行比较分析，并探讨它们之间的关系。方法采用电化学发光免疫分析方法检测HBeAg水平，采用实时荧光定量PCR检测HBV-DNA含量。结果当血清HBV-DNA拷贝数〈1×10^3或〉1×10^7时，血清HBeAg阳性者与HBeAg阴性者之间有显著差异（P〈0．01）。当血清HBV-DNA拷贝数为1×10^3-1×10^7时，血清HBeAg阳性者与HBeAg阴性者之间无显著差异（P〉0．05）。结论HBeAg水平与HBV-DNA含量有一定的相关性，但二者并不完全平行。

Objective To investigate the Correlations between the level of HBeAg and HBV-DNA in patients with Hepatitis B. Methods HBeAg was detected by electrochemiluminescence immunoassay method, HBV-DNA was detected by real time fluorescent PCR technique. Results When HBV-DNA copys was 〈1 × 10^3 or〉1 × 10^7, it was significant difference （P〈0.01） between HBeAg （-） group and HBeAg （＋） group. When HBV-DNA copys was 1 × 10^3-1 × 10^7, it was no significant difference （P〉0.05） between HBeAg （-） group and HBeAg （＋） group. Conclusions HBeAg is correlated with HBV-DNA, but the correlation is not completely parallel.