培美曲塞在肺癌治疗中的新进展

Progress of Pemetrexed in Lung Cancer Treatment

随着化疗药物对非小细胞肺癌的疗效进入平台期,培美曲塞,一种多靶点抗代谢的细胞毒药物,给非小细胞肺癌患者带来了治疗希望。其在非小细胞肺癌治疗中的地位逐渐得到认可。本文对此药在非小细胞肺癌一线、二线、维持治疗和辅助放化疗方面最新的研究进展进行了回顾和展望。

As the chemotherapy drug for non-small cell lung cancer into the plateau,pemetrexed (brand name Alimta),a multi-target folate antimetabolites,brings hope for non-small cell lung cancer treatment.The role of pemetrexed in the treatment of non-small cell lung cancer has been gradually recognized.The latest progresses of pemetrexed in first-line treatment,second-line treatment,maintenance treatment,and adjuvant chemotherapy of non-small cell lung cancer are reviewed in the article.