肺炎支原体肺炎患儿血清细胞因子与免疫球蛋白的检测及其临床意义

Clinical significance of serum cytokines and immunoglobulin levels in children with mycoplasma pneumoniae pneumonia

目的探讨检测肺炎支原体肺炎(MPP)患儿血清细胞因子(IL-6、IL-8、TNF-α)、免疫球蛋白(IgA、IgM、IgG)及补体(C3、C4)的临床意义。方法 60例MPP患儿(观察组)和60例健康儿童(正常对照组)为研究对象,采用放射免疫分析法测定IL-6、IL-12、TNF-α,采用速率散射比浊法测定血清免疫球蛋白(Ig)和补体(C)。结果观察组血清IL-6、IL-8的水平与正常对照组比较上升(P<0.05);而TNF-α水平2组比较差异无统计学意义(P>0.05);观察组血清免疫球蛋白IgA、IgM、IgG水平、补体C水平与正常对照组比较上升(P<0.05)。结论血清IL-6、IL-8、免疫球蛋白IgA、IgM、IgG,补体C3、4在MPP中起着重要作用,检测这些指标可以较准确地判定MMP患儿病情和预后,值得临床推广应用。

Objective To investigate the clinical significance of detecting serum cytokines （IL-6, IL-8 and TNF-a）, immunoglobulins （IgA, lgM and IgG） and complements （C3 and CA ） levels in children with mycoplasma pneumoniae pneumonia （MPP）. Methods 60 children with MPP （ observation group ） and 60 healthy children （control group） were enrolled in the study. The serum levels of IL-6, IL-8 and TNF-ot were detected by ELISA method, the serum levels of immunoglobulins （ IgA, IgM and IgG） and complements （ C3 and CA） were determined by rate nephelometry method. Results The serum levels of IL-6 and IL-8 in observation group were significantly higher than those of control group （ P 〈 0. 05 ）, however there was no significant difference in TNF-a levels between the two groups （ P 〉 0.05 ）. The serum levels of IgA, IgM, IgG, C3 and CA in observati on group were significantly higher than those of control group （ P 〈 0. 05 ）. Conclusion The serum levels of IL- 6 and IL-8, immunoglobulins （IgA, IgM and IgG） and complements （C3 and CA） play an important role in MPP. The detection of these parameters can more accurately determine the disease condition and patients＇ prognosis, which is worthy to be popularized.