1Wang DS,Dickson DW,Malter JS.Beta-Amyloid Degradation and Alzheimer's Disease[J].J Biomed Biotechnol(S1110-7243),2006,2006(3):58406-58406.
2Iwata N,Tsubuki S,Takaki Y,et al.Metabolic Regulation of Brain Abeta by Neprilysin[J].Science(S0193-4511),2001,292(5521):1550-1552.
3Yasojima K,McGeer EG,McGeer PL.Relationship between Beta Amyloid Peptide Generating Molecules and Neprilysin in Alzheimer Disease and Normal Brain[J].Brain Res(S0006-8993),2001,919(1):115-121.
4Iwata N,Higuchi M,Saido TC.Metabolism of Amyloid-beta Peptide and Alzheimer's Disease[J].Pharmacol Ther(S0163-7258),2005,108(2):129-148.
5El-Amouri SS,Zhu H,Yu J,et al.Neprilysin:an Enzyme Candidate to Slow the Progression of Alzheimer's Disease[J].Am J Pathol(S0002-9440),2008,172(5):1342-1354.
7Meilandt WJ,Cisse M,Ho K,et al.Neprilysin Overexpression Inhibits Plaque Formation but Fails to Reduce Pathogenic Abeta Oligomers and Associated Cognitive Deficits in Human Amyloid Precursor Pprotein Transgenic Mice[J].J Neurosci(S0270-6474),2009,29(7):1977-1986.
8Caccamo A,Oddo S,Sugarman MC,et al.Age-and Region-dependent Alterations in Abeta-degrading Enzymes:Implications for Abeta-induced Disorders[J].Neurobiol Aging(S0197-4580),2005,26(5):645-654.
9Yasojima K,Akiyama H,McGeer EG,et al.Reduced Neprilysin in High Plaque Areas of Alzheimer Brain:a Possible Relationship to Deficient Degradation of Beta-amyloid Peptide[J].Neurosci Lett(S0304-3940),2001,297(2):97-100.
10Maruyama M,Higuchi M,Takaki Y,et al.Cerebrospinal Fluid Neprilysin is Reduced in Prodromal Alzheimer's Disease[J].Ann Neurol(S0364-5134),2005,57(6):832-842.
二级参考文献11
1Behl C, Moosmann B. Oxidative nerve cell death in Alzheimer' s disease and stroke:antioxidants as neuroprotective compounds [J]. Biol Chem, 2002, 383(3-4):521-536.
2Dang H, Martin M V, Chambers S, et al. Spatial relationship between synapse loss and beta-amyloid deposition in Tg2576 mice[J]. Comp Neurol, 2007, 500(2):311-321.
3Leissring M A, Farris W, Chang A Y, et al. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death I J]. Neuron, 2003, 40(6) : 1087-1093.
4Meberg P J, Miller M W. Culturing hippocampal and cortical neurons[J]. Methods Cell Biol, 2003, 71:111-127.
5Cho J, Kim Y H. Protection of cultured rat cortical neurons from excitotoxicity by asarone, a major essential oil component in the rhizomes of Acorus gramineus[J]. Life Sci, 2002, 71 (5) :591-599.
6Zhang N Y, Kitagawa K, Wu B, et al. Chloride-dependency of amyloid beta protein-induced enhancement of glutamate neurotoxicity in cultured rat hippocampal neurons [ J ]. Neurosci Lett, 2006, 399(1-2) : 175-180.
7Pike C J, Walencewicz A J, Clabe C G, et al. In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity[J]. Brain Res, 1991, 563(1-2) :311.
8Yamin R, Bagchi S, Hildebrant R, et al. Acyl peptide hydrolase, a serine proteinase isolated from conditioned medium of neumblastoma cells, degrades the amyloid-beta peptide [ J ]. Neurochem, 2007, 100(2) :458-467.
9Miners J S, Van Helmond Z, Chalmers K, et al. Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy [ J]. Neuropathol Exp Neurol, 2006, 65(10):1012-1021.
10Yoshokawa K, Nishimura D. Alzheimer disease and apoptosis [J]. Clin Exp Med, 2003, 205(10):805-810.
2Chalmers KA,Barker R,Passmore PA,et al.LRP-1 variation is not associated with risk of Alzheimer' s disease[J].Int J Mol Epidemiol Genet,2010,1:104-113.
3Kubiak-Wlek y A,Niemir ZI.Neprilysin-structure of the gene and protein product and the localization of expression[J].Pol Merkur Lekarsk,2009,27(157):48-50.
4Miners S,van Helmond Z,Barker R,et al.Genetic variation in MME in relation to neprilysin protein and enzyme activity,Aβ levels,and Alzheimer' s disease risk[J].Int J Mol Epidemiol Genet,2012,3(1):30-38.
5Xu Ji,Li W,Bao X,et al.Association of putative? functional variants in the PLAU gene and the PLAUR gene with myocardial infarction[J].Clin Sci (Lond),2010,119(8):353-359.
6Zhang YW1,Thompson R,Zhang H,et al.APP processing in Alzheimer ' s disease[J].Mol Brain,2011,4:3.
7Miners JS,Kehoe P,Love S.Neprilysin protects against cerebral amyloid angiopathy and Aβ-induced degeneration of cerebrovascular smooth muscle cells[J].Brain Pathol,2011,21(5):594-605.
8Wang R1,Wang S,Malter JS,et al.Effects of HNE-modification induced by Abeta on neprilysin expression and activity in SH-SY5Y cella[J].J Neurochem,2009,108(4):1 072-1 082.
9Miners S,van Helmond Z,Barker R,et al.Genetic variation in MME in relation to neprilysin protein and enzyme activity,Aβ levels,and Alzheimer's disease risk[J].Int J Mol Epidemiol Genet,2012,3(1):30-38.
10Barker R1,Love S,Kehoe PG.Plasminogen and plasmin in Alzheimer's disease[J].Brain Res,2010,1 355:7-15.