摘要
目的:研究端粒酶逆转录酶(hTERT)在结肠癌中的表达及其与Survivin和bcl-2表达的关系。方法:应用免疫组织化学SABC法检测52例结肠癌及其相应癌旁正常组织中hTERT、Survivin和bcl-2的表达。结果:52例结肠癌组织中hTERT表达阳性率为80.8%,而相应癌旁正常结肠组织中无一例阳性表达。hTERT表达的上调与患者性别、年龄、肿瘤浸润深度无明显相关(P>0.05),而与肿瘤分化程度、淋巴结转移、Dukes分期明显相关(P<0.05)。在52例结肠癌组织中hTERT与Survivin以及hTERT与bcl-2的表达之间呈正相关(r=0.589,P<0.05;r=0.559,P<0.05)。结论:hTERT表达的上调与结肠癌的发生、发展、恶性程度有着密切的关系;结肠癌中hTERT的表达与Survivin和bcl-2的表达密切相关。
Objective： To investigate the expression of hTERT in colorectal cancer and its relationships between the expression of Survivin and bcl-2. Methods： The expression of hTERT,Survivin and bcl-2 were detected in 52 cases of tumor tissue and tumor-adjacent norma1 tissue by immunohisto-chemical method of SABC. Results： The positive rate of hTERT in colorectal cancer was 80.8% , hTERT was not expressed in normal tissue. The over expression of hTERT had no relation with sex, age and tumor depth （P0.05）. It was significantly related to tumor differentiation, lymph node metastasis,Dukes staging（P0.05）.There were significant positive correlations between hTERT and Survivin together with hTERT and bcl-2 in 52 tissues（r=0.589, P0.05; r=0.559, P0.05）. Conclusion： These data indicates that the abnormal expression of the hTERT might play an importmant role in occurrence, development and malignant evolution of colorectal cancer, there are close relationships between hTERT, Survivin and bcl-2 .
出处
《中国现代普通外科进展》
CAS
2010年第3期173-176,共4页
Chinese Journal of Current Advances in General Surgery
