期刊文献+

血清葡萄糖6-磷酸异构酶诊断类风湿关节炎的价值分析 被引量:3

下载PDF
导出
摘要 目的:探讨血清葡萄糖6-磷酸异构酶诊断类风湿关节炎的价值。方法:选取RA患者98例,其他风湿患者90例,并选同期健康体检者样本共95例作对照。提取血清、采用双抗体夹心酶联免疫吸附试验。GPI浓度以0.201μg/ml为分界点,>0.201μg/ml认为阳性结果,≤0.201μg/ml为阴性结果。结果:血清GPI浓度:RA患者为1.740±2.821μg/ml,其他风湿病患者为0.094±0.258μg/ml,健康体检者为0.087±0.231μg/ml,RA患者血清中GPI浓度显著高于其他患者和健康体检者(P<0.01)。血清GPI阳性RA患者为70.41%,其他风湿病患者为11.58%,健康体检者为2.11%,RA患者阳性率明显高于其他患者和健康体检者(P<0.01)。结论:GPI对早期诊断RA具有重要临床意义,与RF联合检测可提高诊断的特异性,且与RA病情活动具有相关性。
作者 颜峰 崔艳平
出处 《中国社区医师(医学专业)》 2010年第18期166-167,共2页
  • 相关文献

参考文献4

二级参考文献18

  • 1Schubert D, Maier B, Morawietz L, et al.Immunization with glucose-6-phosphate isomerase induces T celldependent peripheral polyarthritis in genetically unaltered mice [J]. J Immunol, 2001,172(7): 4503-4509.
  • 2Matsumoto I, Lee DM, Goldbach-Mansky R, et al. Low prevalence of antibodies to glucose-6-phosphate isomerase in patients with rheumatoid arthritis and a spectrum of other chronic autoimmune disorders[J]. Arthritis Rheum. 2003, 48(4): 944-954.
  • 3Herve CA, Wait R, Venables PJ. Glucose-6-phosphate isomerase is not a specific autoantigen in rheumatoid arthritis [J]. Rheumatology (Oxford). 2003, 42(8): 986-988.
  • 4van Gaalen FA, Toes RE, Ditzel HJ. Association of autoantibodies to glucose-6-phosphate isomerase with extraarticular complications in rheumatoid arthritis[J]. Arthritis Rheum, 2004, 50(2): 395-399.
  • 5Muraki Y, Matsumoto I, Chino Y, et al. Glucose-6-phosphate iso- merase variants play a key role in the generation of anti-GPI antibodies: possible mechanism of autoantibody production[J]. Bioehem Biophys Res Commun. 2004, 323(2): 518-522.
  • 6Schaller M, Stohl W, Benoit V, et al. Patients with inflammatory arthritic diseases harbor elevated serum and synovial fluid levels of free and immune-complexcd glucose-6-phosphate isomerase(G6PI)[J]. Biochem Biophys Res Commun, 2006, 349(2): 838-845.
  • 7Schubert D, Schmidt M, Zaiss D, et al. Autoantibodies to GPI and creatine kinase in RA. Nat Immunol, 2002, 3: 412-413.
  • 8Schaller M, Burton DR, Ditzel HJ. Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease. Nat Immunol, 2001, 2: 746-753.
  • 9Cha HS, Kim TJ, Kim JY, et al. Autoantibodies to glucose-6-phosphate isomerase are elevated in the synovial fluid of rheumatoid arthritis patients. Scand J Rheumatol, 2004, 33:179-184.
  • 10Kim JY, Lee MH, Jung KI, et al. Detection of antibodies against glucose 6-phosphate isomerase in synovial fluid rheumatoid arthritis using surface plasmon resonance (BIAcore). Exp Mol Med, 2003, 35: 310-316.

共引文献81

同被引文献40

引证文献3

二级引证文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部