摘要
目的探讨怀化地区麻阳苗族自治县苗族人群幽门螺杆菌(Hp)感染特别是其细胞色素相关基因(CagA)与胃癌的相关性。方法收集湖南怀化麻阳苗族自治县人民医院2001～2008年经病理检查确诊的胃癌患者100例,其中苗族52例,汉族48例,苗族患者平均(60.12±12.35)岁,汉族患者平均年龄(67.75±11.64)岁。分别检测两族胃癌患者Hp和HpCaA基因株的感染率。结果苗族人群胃癌组Hp的阳性率均显著高于汉族人群胃癌组(P<0.05),苗族人群胃癌组HpCagA基因株阳性率均显著高于汉族人群胃癌(P<0.05)。结论 HpCagA基因株感染与胃癌关系密切,苗族人群胃癌患者CagA基因株感染率显著高于汉族胃癌患者组,这是否是苗族人群胃癌发病较早、发病率较高的一种原因尚待进一步研究。
Objective To investigate the relations between HP CageA and gastric carcinoma in Auto- county Miao of Mayang Huaihua region. Methods 100 patients with gastric carcinoma, among which 52 cases were Miao people. Means age was （ 60. 12 ± 12. 35 ） years and 48 Han people, means age was （ 67.75 ± 11.64 ） years. Hpand HpCagA were detected in patients with gastric carcinoma. Results The rate of infection Hp in Miao people with gastric carcinoma group was significantly higher than those Han people group（ P 〈 0. 05 ）. The rate of infection Hp CagA in Miao people with gastric carcinoma group was significantly higher than those Han people group（ P 〈 0. 05 ）. Conclusion There is a significant difference of Hp CageA in gastric carcinoma between Miao people and Han people. The early on set and high incidence rate of gastric carcinoma in Miao peo- ple may be due to their high Hp CagA.
出处
《中国实用医药》
2010年第17期57-58,共2页
China Practical Medicine
关键词
胃癌
幽门螺杆菌
苗族
Gastric carcinoma
Helicobacterpylori
Miao people
