替米沙坦治疗肾性高血压的动态血压变化特点

Study of characteristics of ambulatory blood pressure in Telmisartan treated renal hypertension

[目的]利用动态血压评价替米沙坦治疗轻中度肾性高血压的效果。[方法]采用自身对照的方法,对89例轻中度肾性高血压患者,口服替米沙坦80 mg,1次/d,疗程4周,于治疗前后进行24 h动态血压监测,并对治疗前后的24 h、日间、夜间血压平均值、血压负荷值、血压变异性和血压昼夜节律性进行统计分析。[结果]用药后患者24 h、日间、夜间SBP和DBP的血压平均值、血压负荷值、血压变异性与用药前比较差异均有显著性意义(P<0.01),SBP、DBP夜间下降率用药后大于用药前[(10±9)%比(2±8)%,(8±10)%比(3±13)%]差异有显著性意义(P<0.01或<0.05)。[结论]替米沙坦治疗轻中度肾性高血压有效、平稳并能恢复血压昼夜节律性。

[Objective] To evaluate the effect of telmisartan in mild and moderate renal hypertension by ambulatory blood pressure.[Methods] Eight-nine patients with mild to moderate renal hypertension were treated with 80 mg telmisartan once a day for 4 weeks.Twenty-four hour ambulatory blood pressure was monitored before and after telmisartan taken.Average blood pressure of 24 h,daytime,night-time,blood pressure load,blood pressure variability and circadian rhythm of blood pressure.[Results] After 4 weeks of telmisartan treatment,average SBP and DBP of 24 h,daytime,night-time,blood pressure load values,blood pressure variability were significant different from those in pre-treatment（P0.01）.Night-time decline rate of SBP,DBP after treatment were statistically significant（P0.01 or 0.05） more than that before treatment [（10±9）% vs（2±8）% and（8±10）% vs（3±13）%].[Conclusion] Telmisartan in patients with mild to moderate renal hypertension is effective,smooth and can restore blood pressure circadian rhythm.