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低砷染毒致小鼠肝脏氧化损伤的影响 被引量：8

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摘要 目的动态观察低剂量砷染毒小鼠致肝脏脂质过氧化情况。方法96只健康雄性KM小鼠随机分组,设0、50、500和5000μg/L4个组,再将每个剂量组分4、6和8周3个染毒时间点,经饮水染毒,测定肝脏和血液中总砷含量、肝组织脂质过氧化和抗氧化水平。结果血砷、肝脏砷含量随着染毒时间和染毒剂量的增加而逐渐增高,差异有统计学意义(P<0.05)。在肝组织中,丙二醛(MDA)含量均随染毒时间和染毒剂量的增加而增高,差异有统计学意义(P<0.05);过氧化物歧化酶(SOD)活性和谷胱甘肽过氧化物酶(GSH-Px)活性则是均随着染毒时间和染毒剂量的增加出现先增高后降低的现象,其增高差异均有统计学意义(P<0.05)。GSH-Px活性降低与对照组之间,差异有统计学意义(P<0.05),而SOD活性降低与对照组相比无明显差异(P>0.05)。结论在本试验条件下,低砷可以诱导小鼠肝脏抗氧化损伤系统出现适应性的增高,但随着剂量和作用时间增加最终会造成小鼠的氧化损伤。
作者 高艳芳 郭有 苏林梁 郭鲜妮 裴秋玲
机构地区 赣南医学院预防医学系 山西医科大学卫生毒理学教研室
出处 《毒理学杂志》 CAS CSCD 北大核心 2010年第2期133-135,共3页 Journal of Toxicology
基金 山西省回国人员基金(200527) 山西省科技攻关项目(2006031087-11)
关键词 亚砷酸钠 脂质过氧化 肝脏
分类号 R99 [医药卫生—毒理学]
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参考文献10

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二级参考文献56

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毒理学杂志
2010年 第2期

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