多发腔隙性脑梗死的脑血管功能变化

The changes of cerebrovascular function in the patients with multiple lacunar infarction.

目的系统观察多发腔隙性脑梗死（ＭＬＩ）不同时期脑血管功能的变化。方法依发病时间将８５例ＭＬＩ患者分成急性ＭＬＩ组及慢性ＭＬＩ组。同时选取年龄、性别及既往病史与前两组匹配的脑血管病危险因素组（ＣＶＤＲＦ）做对照。用脑血管血液动力学指标估价脑血管功能。结果与ＣＶＤＲＦ组相比，ＭＬＩ组脑循环显著异常。与ＭＬＩ急性组相比，慢性组脑循环有部分改善。ＭＬＩ组，甚至ＣＶＤＲＦ组，均出现脑血管弹性及自动调节功能下降。结论ＭＬＩ患者梗死急性期、慢性期及梗死之前均出现了脑血管功能的异常，前两期下降更明显。

s Objective To investigate the changes of cerebrovascular function in the patients with multiple lacunar infarct (MLI) at different stage. Methods Eighty five cases of MLI were divided into acute MLI (AMLI) and chronic MLI (CMLI) group according to the onset time. The patients with cerebrovascular disease risk factors (CVDRF), but without MLI were chosen as control. Three groups were well matched in age, sex and previous history of diseases. Cerebrovascular function was evaluated by cerebral vessel hemodynamic indexes (CVDI).Results Compared with CVDRF, the cerebral circulation was impaired remarkably in AMLI and CMLI. Compared with AMLI, cerebrovascular function in CMLI was improved to a certain extent. In AMLI, CMLI and CVDRF, cerebrovascular elasticitys and autoregulations were deteriorated.Conclusions Cerebrovascular function abnormality exists in both MLI and in CVDRF, and the former is more obvious.