1～24月婴幼儿胰岛素样生长因子-1水平及与生长发育的关系

Insulin-like growth factor 1 levels and their association with growth and development in infants aged 1-24 months

目的分析1～24月龄婴幼儿血清胰岛素样生长因子-1(IGF-1)水平及其与生长发育的关系。方法 525名健康婴幼儿入选本研究(早产儿125名,足月儿400名),测量体重/身长,酶联免疫吸附法检测血清IGF-1水平。结果早产组婴儿期血清IGF-1水平在生后1.5月为最低(86±60ng/mL),此后一直维持较高水平,生后4～12月显著高于足月组。足月组婴儿期血清IGF-1水平在生后1.5月为最高(116±52ng/mL),此后缓慢下降,生后8月时降至最低(69±58ng/mL)。不论是早产儿还是足月儿体重/身长SDS与血清IGF-I水平均存在着正相关关系。结论血清IGF-1水平均与婴幼儿期生长发育速度密切相关。

Objective To study serum insulin-like growth factor 1（IGF-1）levels and their association with growth and development in infants aged 1-24 mouths.Methods A total of 525 healthy infants（125 preterm,400 term）were enrolled.Serum IGF-1 levels were measured using ELISA 1.5,4,6,8,12,18 and 24 months after birth.The body weight and body length were simultaneously measured.Results Serum IGF-1 levels were the lowest in preterm infants 1.5 months after birth（86± 60 ng/mL）.Thereafter,serum IGF-1 levels increased,and were significantly higher than those in term infants between 4 and 12 months after birth.Serum IGF-1 levels in term infants were the highest（116±52 ng/mL）1.5 months after birth during their life of 12 months old.Thereafter,serum IGF-1 levels decreased and reached to a nadir（69±58 ng/mL）8 months after birth.IGF-I levels were positively correlated with the weight and the height（SDS）in both preterm and term infants.Conclusions Serum IGF-1 levels are closely associated with growth and development in infants.