不同糖耐量状态下空腹血浆肥胖抑制素水平及其与脂代谢的相关性

Fasting plasma obestatin levels in patients with different glucose tolerance and its association with lipid metabolism

目的 探讨不同糖耐量状态下血浆肥胖抑制素（obestatin）的水平变化及其与脂代谢的相关性.方法 将84例既往无糖尿病史受试者根据口服葡萄糖耐量试验结果分为正常糖耐量组（NGT）、糖耐量异常组（IGT）和2型糖尿病组（DM）,比较各组间空腹血浆obestatin水平及代谢指标的差异,并分析obestatin与各代谢指标的相关性.结果 空腹血浆obestatin在NGT（3.55±0.57）ng/ml、IGT（3.25±0.29）ng/ml及DM（2.82±0.78）ng/ml组间递减（P＜0.01）;三酰甘油（TG）及低密度脂蛋白胆固醇（LDL-C）水平在3组内递增（P＜0.05）;obestatin与腰臀比、TG及LDL-C独立相关（P＜0.01）,回归方程为obestatin=6.953-3.412×W/H-0.175×TG-0.123×LDL-C.结论 IGT和DM患者空腹血浆obestatin水平下降,Obestatin水平可能与脂代谢相关.

Objective To investigate whether fasting obestatin level is different in patients with impaired glucose tolerance or type 2 diabetes, and to explore the association between obestatin and lipid metabolism. Methods Eighty-four subjects without known diabetes were divided into three groups： normal glucose tolerance（NGT）, impaired glucose tolerance （IGT） and type 2 diabetes （DM） Plasma obestatin levels were measured with a radioimmunoassay. The relationship between fasting obestatin levels and metabolic parameters was also analyzed. Results Fasting obestatin levels were lower in DM group [（2.82±0.78）ng/ml] and IGT group [（3.25±0.29）ng/ml] than in NGT group[（3.55±0.57） ng/ml, P＜0.01]. Triglycerides and low density lipoprotein cholesterol levels gradually increased among the three groups （P＜0.05）. Multiple linear regression analysis revealed fasting obestatin level was independently associated with waist-to-hip ratio, triglyeride and low density lipoprotein cholesterol. The regression equation was obestatin=6.953-3.412×W/H-0.175×TG-0.123×LDL-C. Conclusions The decreased obestatin may be associated with IGR and T2DM, and obestatin level may be associated with lipid metabolism.