3种梅毒非特异性试剂检测脑脊液的结果分析

Analysis of Treponema Pallidum Test of Cerebrospinal Fluid with Three Kinds of Non-specific Treponema Pallidum Reagents

目的通过用3种试剂对患者脑脊液进行梅毒非特异性试验结果的分析,优选出神经梅毒的诊断试剂。方法使用VDRL1,VDRL2和RPR试剂同时对140例梅毒患者脑脊液标本进行梅毒非特异性试验。结果 140例脑脊液标本,检出TPPA阳性且VDRL或RPR定性阳性的合计26例,VDRL2和VDRL1,VDRL2和RPR定性实验结果比较,差异均有统计学意义(P均<0.05)。结论用脑脊液检查进行神经梅毒的诊断和鉴别诊断时,RPR不能代替VDRL,且VDRL2优于VDRL1,建议使用VDRL试剂2。

Objective Picking out the optimized regents for Diagnosis of neurosyphilis through serological results by three kinds of non-treponemal antigens. Methods Non-treponemal antigen tests were performed on 140 cerebrospinal fluid specimens of patients with syphilis by three different reagents. Results There were significant difference between VDRL1 and VDRL2 qualitative experimental results（ P 〈 0.05）. There were also significant difference between VDRL2 and qualitative RPR test results （P 〈 0.05 ）. Twenty-six cases of TPPA-positive and non-specific test positive for syphilis were screened among 140 cases of cerebrospinal fluid specimens, Conclusion VDRL can＇t be replaced by PRP in syphilis diagnosis, and VDRL2 is better than VDRL1 in diagnosis which should be recommand to use.