以复视为突出表现的神经梅毒文献及分析

Neurosyphilis presenting as Diplopia:A Literature Review

目的探讨以复视为突出表现的神经梅毒的临床特征。方法计算机检索Medline、Embase和中国生物医学文献数据库(CBM),收集所有因神经梅毒引起复视的病例报告,由两名研究者独立提取资料与评价质量,应用Excel2007软件行数据分析。结果纳入12例患者(12篇病例报告),其临床特征有:男性多见,以复视为突出表现,有脑脊液改变,影像学检查无特异性,青霉素疗效好,预后较好。结论多种类型神经梅毒均可以复视为突出表现,诊断常被推迟,遇到复视患者要有诊断神经梅毒警惕性,青霉素为首选治疗药物。

Objective To investigate the clinical features of neurosyphilis presenting as diplopia. Methods Case reports were identified from Medline, Embase and CBM. Case reports of diplopia attributed to neurosyphilis were enrolled. Two reviewers independently assessed studies quality and extracted date. The Excel 2007 software was used for statistical analysis. Results Twelve studies involving 12 patients were evaluated. The clinical feature of neurosyphilis presenting as diplopia included： more often in man, diplopia being key symptom, changes in cerebrospinal fluid, no specific neuroimaging, good response to penicillin, and good prognosis. Conclusion Diplopia as one of the prominent symptom can be found in diverse types of neu- rosyphilis, which diagnosis is often delayed. More attention should be paid to the neurosyphil.s diagnosis of patients with diplopia. Penicillin remains the mainstay of treatment for neurosyphilis.