清肺利湿解毒方药治疗痤疮的临床观察及对血清相关性激素水平的影响

Clinical Observation of Lung-Clearing,Dampness-Eliminating and Toxicity-Removing Formulations in Treating Acne Valgaris and change of Sexhormone

目的评价清肺利湿解毒方药治疗寻常性痤疮的疗效及安全性,并观察其对痤疮患者性激素的调节作用。方法 100例寻常性痤疮患者内服本科自拟清肺利湿解毒中药方治疗8周,评价其临床疗效及安全性,并观察50例患者治疗前后外周血中睾酮(T)、雌二醇(E2)、黄体生成素(LH)、促卵泡素(FSH)、催乳素(PRL)、孕酮(PRG)的变化。结果临床治愈38例(38.0%),显效47例(47.0%),有效率为85.0%,无不良反应。其中女性痤疮患者的T及PRL水平治疗前后有显著变化(P<0.05),男性患者激素水平治疗前后均无明显变化(P>0.05)。结论清肺利湿解毒方治疗寻常性痤疮具有明显的临床疗效,且无不良反应,其可能通过调节机体性激素水平达到治疗寻常痤疮的目的 。

Objective To evaluate the clinical efficacy and the safety of Lung-Clearing, Dampness-Eliminating and Toxicity-Removing Formulations in treating Ache Valgaris and investigate the change of the sexual hormone. Methods One hundred patients of Acne Valgaris took Lung-Clearing, Dampness-Eliminating and Toxicity- Removing Formulations. The clinical efficacy, safety and the change of level of follicle stimulating hormone （ FSH ） , luteinizing hormone （LH） , testosterone （T） , estradiol （ E2 ） , prog （P）. prolactin （PRL） in 50 patients ＇after 8 weeks were assayed. Results Thirty-eight patients （38.0%） were cured,47 cases （47.0%） showed markedly effective, and total effective rate was 85.0%, No adverse reactions occurred. T and PRL level in women with acne changed significantly before and after treatment（P 〈0.05）, and hormone levels in men showed no significant change （ P 〉 0. 05 ）. Conclusions Clinical efficacy of Lung-Clearing, Dampness- Eliminating and Toxicity-Removing Formulations was obvious without adverse reactions, and it may take the role through regulating the hormones level .