吲哚美辛栓不良反应的回顾性分析

Retrospecitve Analyses of Adverse Drug Reactions of Indometacin Suppositories

目的分析吲哚美辛栓所致不良反应的临床特征、相关因素,为临床药物治疗中药品不良反应的防治提供参考依据。方法检索1986年-2009年中国生物医学文献系统吲哚美辛栓的不良反应资料,并加以分析研究。结果得到符合标准的患者24例,不良反应报告中男性多于女性;不良反应以全身性损害最多(12例,50.00%),其次为皮肤及附件损害(2例,8.33%)、循环系统损害(2例,8.33%)、消化系统损害(2例,8.33%);不良反应较为严重。结论患者的年龄、性别等因素能影响不良反应的发生,临床应特别注意吲哚美辛栓引起的休克。

Objective To analyse the clinical features, correlation factors of adverse drug reactions （ADRs） caused by indometacin suppositories and provide beneficial references for preventing and curing the ADRs. Methods The cases of ADRs caused by indometacin suppositories from medical journals of 1986 - 2009 were collected and analyzed. Results Men （16） were more than women （8） in 24 ADRs; Whole-body disorders accounted for 50. 00%, skin and its appendix lesions accounted for 8. 33%, circulatory system disorders accounted for 8. 33%, digestive system lesions accounted for 8. 33%. All ADRs were generally serious. Conclusion Age and gender, etc, can influence the occurrence of ADRs caused by indometacin suppositories. The shock caused by indometacin suppositories should be paid much attention.