突变体p53蛋白与肾细胞癌患者预后

The prognostic value of mutation p53 protein in renal cell carcinoma

目的探讨突变体ｐ５３蛋白（ｍｔｐ５３）与肾细胞癌患者预后关系。方法对９７例根治性切除术的肾细胞癌石蜡包埋标本采用免疫组化ＬＳＡＢ法测定ｍｔｐ５３。结果阳性者３３例，５年生存率６１５％；阴性者６４例，５年生存率８１３％。两组生存率差异有显著性（Ｐ＜００５）。ＣＯＸ比例风险模型分析提示ｍｔｐ５３不是独立预后因素（Ｐ＞０１０）。结论ｍｔｐ５３对判断肾细胞癌预后有价值。

Objective To elucidate the prognostic value of mutation p53 protein (mtp53). Methods 97 paraffin embedded blocks of renal cell carcinoma were studied by immunohistochemical stai ning (LSAB). Results mtp53 was positive in 33 cases.The 5 year survival in patients with positive p53 was 61.5%,and in patients with negative p53 81.3%.The difference was significant ( P <0.05). Conclusions mtp53 has prognostic value,but is not the sole factor.