电化学治疗前列腺增生症的体外实验及临床研究

Electrochemical treatment of benign prostatic hyperplasia

目的探讨经尿道电化学治疗前列腺增生的作用机制及临床疗效。方法自１９９７年１０月～１９９８年５月，应用前列腺电解治疗仪对离体前列腺组织行体外实验，临床治疗前列腺增生患者１９例。结果体外研究显示，经尿道电解治疗可使尿道周围０．７～０．９ｃｍ范围内组织发生不可逆性坏死、变性；１９例前列腺增生伴尿潴留患者接受了３００～４００库仑电量的治疗，总有效率７４％。结论经尿道电化学治疗前列腺增生操作简单，无需麻醉，耐受性好，安全有效，尤其适合于不宜手术治疗的患者。

Objective To make clear the clinical effectiveness and the therapeutic mechanism of electrochemical treatment of benign prostatic hyperplasia (BPH ). Methods From Oct.1997 to May 1998,the QZD electrolytic therapeutic device was used on prostate specimens obtained on suprapubic prostatectomy and then for the treatmen of 19 BPH patients. Results Irreversible pathological changes occurred and increased with the accumulation of therapeutic power.19 BPH patients with urinary retention received a 300～400 Coulomb for 60～100 minutes with an effective rate of 74%. Conclusions Transurethral electrochemical treatment was beleived to be simple,safe,effective and well tolerable especialy for the high risk patients.