摘要
The direct asymmetric three-component reaction of an aromatic (or cinnamic) aldehyde, an amine and a phosphite was investigated by employing chiral BrΦnsted acid. In general, modest to good enantioselectivities (31%–87% ee) could be obtained in acceptable isolated yields (61%–91%) for a series of substrates.
The direct asymmetric three-component reaction of an aromatic （or cinnamic） aldehyde, an amine and a phosphite was investigated by employing chiral BrФnsted acid. In general, modest to good enantioselectivities （31%-87% ee） could be obtained in acceptable isolated yields （61%-91%） for a series of substrates.
基金
supported by the National Natural Science Foundation of China (20772091)
Tianjin Municipal Science and Technology Commis-sion (07JCZDJC04700)
