摘要
A new enantioselective aldol-type reaction of 4-hydroxycoumarins and ethyl trifluoropyruvate has been developed. In the presence of (DHQD)2PHAL (5 mol%), ethyl trifluoropyruvate could react with various 4-hydroxycoumarins to afford novel 4-hydroxycoumarin derivatives containing a tertiary trifluoromethyl alcohol center in good yields with moderate enantioselectivities.
A new enantioselective aldol-type reaction of 4-hydroxycoumarins and ethyl trifluoropyruvate has been developed. In the presence of （DHQD）2PHAL （5 mol%）, ethyl trifluoropyruvate could react with various 4-hydroxycoumarins to afford novel 4-hydroxycoumarin derivatives containing a tertiary trifluoromethyl alcohol center in good yields with moderate enantioselectivities.
基金
supported by Sichuan Provincial Government (07ZQ026027)
关键词
对映选择性
三氟甲基
金鸡纳生物碱
反应
羟基
改性
催化
乙基
4-hydroxycoumarin, tertiary trifluoromethyl alcohol, asymmtric synthesis, cinchona alkaloid, organocatalysts
