Chiral pyrrolidine-azole conjugates: Simple and efficient asymmetric organocatalysts for Michael addition to nitrostyrenes 被引量：1

Chiral pyrrolidine-azole conjugates: Simple and efficient asymmetric organocatalysts for Michael addition to nitrostyrenes

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摘要 Simple pyrrolidine-azole conjugates have been synthesized and found to be efficient catalysts for asymmetric Michael addition to nitrostyrenes. The identified optimal catalysts, pyrrolidine-azoles 2, 8 and 13, could catalyze the asymmetric Michael addition of a range of Michael donors and nitrostyrenes in high yields (up to 99%) and excellent stereoselectivities (up to 99:1 dr and 97% ee). Simple pyrrolidine-azole conjugates have been synthesized and found to be efficient catalysts for asymmetric Michael addition to nitrostyrenes. The identified optimal catalysts, pyrrolidine-azoles 2, 8 and 13, could catalyze the asymmetric Michael addition of a range of Michael donors and nitrostyrenes in high yields （up to 99%） and excellent stereoselectivities （up to 99：1 dr and 97% ee）.

作者 ZHANG Long XU Hui MI XueLing LUO SanZhong CHENG Jin-Pei

机构地区 Department of Chentistry and State Key Laboratory of Elemento-organic Chemistry Beijing National Laboratory for Molecular Sciences (BNLMS)

出处《Chinese Science Bulletin》 SCIE EI CAS 2010年第17期1735-1741,共7页

基金 supported by the National Natural Science Foundation of China (20421202, 20632060 and 20702052) the Ministry of Science and Technology of China (2008CB617501 and 2009ZX09501-018) and the Chinese Academy of Sciences.

关键词不对称MICHAEL加成有机催化剂吡咯烷迈克尔复合物三氮唑手性高效催化剂 pyrrolidine, azole, organocatalysis, Michael addition, nitrostyrene

分类号 O621.25 [理学—有机化学]

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参考文献61

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2010年第17期

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Chiral pyrrolidine-azole conjugates: Simple and efficient asymmetric organocatalysts for Michael addition to nitrostyrenes 被引量：1

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