法舒地尔治疗急性脑梗死的疗效及对血清神经元特异性烯醇化酶的影响

Efficacy and effect of fasudil on clinical manifestations and serum neurospecific enolase in patients with acute cerebral infarction

目的观察法舒地尔对急性脑梗死患者血清神经元特异性烯醇化酶(NSE)的影响以及临床疗效。方法将80例患者随机分为对照组和法舒地尔治疗组,测定患者治疗前后血清NSE含量、神经功能缺损评分以及Barthel指数(BI)。结果经法舒地尔治疗后10 d,患者血清NSE含量为(12±s 4)μg.L-1,神经功能缺损评分为(13±3)分,BI评分为(68±10)分。与对照组比较,治疗组血清NSE含量和临床神经功能缺损程度评分明显降低(P<0.05),BI评分明显升高(P<0.05)。结论血清NSE水平较好地反映了急性脑梗死的脑损伤程度。法舒地尔治疗可有效降低急性脑梗死患者血清NSE含量和神经功能缺损评分,促进临床神经功能的恢复。

AIM To observe the efficacy and effect of fasudil on clinical manifestations and serum neurospecific enolase（NSE） in the patients with acute cerebral infarction.METHODS Eighty patients with acute cerebral infarction were randomly divided into fasudil treatment group and control group.Before and after therapy,the levels of serum NSE were determined for the evaluation of neurological deficit and Barthel index（BI）.RESULTS After therapy in the fasudil treatment group,the level of serum NSE was（12 ± s 4） μg·L-1,the total score of clinical neurological deficits was（13 ± 3） and the score of BI was（68 ± 10）.Comparing with the control group,the levels of serum NSE and clinical neurological deficit were significantly lower（P 0.05）,but the BI score was significantly higher（P 0.05）.CONCLUSION The NSE level can rather be better reflected damage degree of acute cerebral infarction.Fasudil may decrease the level of serum NSE and clinical neurologic deficit score in patients with acute cerebral infarction.