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醛固酮合酶基因多态性与老年原发性高血压的关系 被引量：4

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摘要 目的探讨醛固酮合酶(CYP11B2)基因-344C/T多态性与老年原发性高血压(EH)的相关性。方法以人群为基础进行老年人EH病例-对照研究,应用PCR-RELP技术对289例武汉地区汉族老年人的CYP11B2基因-344C/T多态性进行分析。结果武汉地区汉族老年人群CYP11B2基因-344C/T多态性以TT和CT为主要基因型,C等位基因较少见。CYP11B2基因-344C/T多态性与老年人EH有相关性(P<0.05)。结论武汉地区汉族老年人群CYP11B2基因-344C/T多态性与EH存在相关性,老年高血压人群携带CC+CT基因型频率较高。
作者 彭慧 胡晓军 陈苏 李峰 晏凯利 陈娟 涂远超
机构地区 湖北省新华医院心内科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2010年第10期1326-1327,共2页 Chinese Journal of Gerontology
基金 湖北省卫生厅科研基金资助(JX3C29)
关键词 高血压 醛固酮 基因 老年人
分类号 R541.409 [医药卫生—心血管疾病]
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参考文献11

  • 1Kupari M,Hautanen A,Lankinen L,et al.Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size,mass,and function[J].Circulation,1998;97(6):569-75.
  • 2Curnow KM,Tusie-Luna MT,Pascoe L,et al.The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex[J].Mol Endocrinol,1991;5(10):1513-22.
  • 3Kawamoto T,Mitsuuchi Y,Toda K,et al.Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocoticoids in humans[J].Proc Natl Acad Sci USA,1992;89(4):1458-62.
  • 4胡晓军,王芳,王晋明,王蕊,牛萍.武汉地区汉族人群醛固酮合酶基因多态性与原发性高血压的关系[J].临床心血管病杂志,2003,19(8):456-458. 被引量：8
  • 5Tamaki S,Iwai N,Tsujita Y,et al.Genetic polymorphism of CYP11B2 gene and hypertension in Japanese[J].Hypertension,1999;33(1-2):266-70.
  • 6Hautanena A,Lankinen L,Kupari M,et al.Associations between aldosterone synthase gene polymorphism and the adrenocortical function in males[J].J Intern Med,1998;244(1):11-8.
  • 7Komiya I,Yamada T,Takara M,et al.Lys(173)Arg and -344T/C variants of CYP11B2 in Japanese patients with low-renin hypertension[J].Hypertension,2000;35(3):699-703.
  • 8Paillard F,Chansel D,Brand E,et al.Genotype-phenotype relationships for the renin-angiotensin-aldosterone system in a normal population[J].Hypertension,1999;34(3):423-9.
  • 9Delles C,Erdmann J,Jacobi J,et al.Aldosterone synthase (CYP11B2) -344C/T polymorphism is associated with left ventricular structure in human arterial hypertension[J].J Am Coll Cardiol,2001;37(3):878-84.
  • 10Schunkert H,Hengstenberg C,Holmer SR,et al.Lack of association between a polymorphism of the aldosterone synthase gene and left ventricular structure[J].Circulation,1999;99(17):2255-60.

二级参考文献20

  • 1Kupari M, Hautanen A, Lankinen L, et al. Association between human aldosterone synthase (CYP11B2)gene polymorphisms and left ventricular size, mass, and function. Circulation, 1998, 97 : 569-575.
  • 2Curnow K M, Tusie-Luna M T, Pascoe L, et al. The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex. Mol Endocrinol, 1991, 5:1513--1522.
  • 3Kawamoto T, Mitsuuchi Y, Toda K, et al. Role of steroid 11-betahydroxylase and steroid 18-hydroxylase in the biosynthesis of glueoeortieoids and mineralocoticoids in humans. Proe Natl Aead Sci USA, 1992, 89:1458-1462.
  • 4White P C, Slutsker L. Haplotype analysis of CYP11B2. Endocr Res, 1995, 21:437--442.
  • 5Tamaki S, Iwai N, Tsujita Y, et al. Genetic polymorphism of CYP11B gene and hypertension in Japanese.Hypertension, 1999,33:266-270.
  • 6Hauntanean A, Lankinen L, Kupari M, et al. Associations between aldosterone synthase gene polymorphism and the adrenocortical function in males. J Intern Med,1998, 244:11-18.
  • 7Komiya I, Yamada T, Takara M, et al. Lys(173)Arg and -344 T/C variants of CYP11B2 in Japanese patients with low-renin hypertension. Hypertension, 2000, 35.699--703.
  • 8Paillard F, Chansel D, Brand E, et al. Genetype-phenotype relationship for the renin-angiotension-aldosterone system in a normal poulation. Hypertension,1999, 34:423--429.
  • 9Delles C, Erdmann J, Jacobi J, et al. Aldosterone synthase (CYP11B2) -344 C/T polymorphism is associated with left ventricular strcture in human arterial hypertension. J Am Coll Cardiol, 2001, 37:878--884.
  • 10Schunkert H, Hengstenberg C, Holmer S R, et al.Lack of association between a polymorphism of the aldosterone synthase gene and left ventricular structure.Circulation, 1999, 99 : 2255-2260.

共引文献42

同被引文献60

引证文献4

二级引证文献16

中国老年学杂志
2010年 第10期

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