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雌激素的非基因组途径在哺乳动物雌性生殖过程中的作用机制 被引量：4

Estrogen Non-genomic Pathway in Female Mammalian Reproduction
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摘要 雌激素的非基因组调节模式在雌性生殖系统中广泛存在.雌激素通过基因组、非基因组及两种调节模式的整合在不同组织中行使多种生理功能.卵巢中雌激素能通过非基因组效应对卵细胞起到保护作用.子宫中雌激素对多种基因的表达都是通过非基因组模式.对雌激素非基因组效应的研究将有利于进一步了解雌激素的作用机制. Non-genomic effects of estrogen exist largely in female reproductive system. Through genomic and non-genomic pathways, and their integration, estrogen performs different physiological functions in various target tissues. In the ovary, estrogen functions as a reactive oxygen scavenger and protects ovarian cells from apoptosis through non-genomic pathway. Estrogen also regulates the expression of uterine genes in an estrogen receptor-independent manner. The review on estrogen non-genomic effects will be beneficial for understanding the mechanism of estrogen action.
作者 梁晓欢 杨增明
机构地区 东北农业大学生命科学学院 厦门大学生命科学学院
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2010年第6期594-599,共6页 Progress In Biochemistry and Biophysics
基金 国家自然科学基金重点资助项目(30930013)~~
关键词 雌激素 非基因组调节 子宫 卵巢 estrogen non-genomic action uterus ovary
分类号 Q492 [生物学—生理学]
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参考文献30

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同被引文献83

  • 1诸定寿,史小林,梁元晶,翁静,许晴,路欣.孕酮受体在雌性小鼠生殖系统中的分布及RU486对其影响[J].中国组织化学与细胞化学杂志,1997,6(3):95-98. 被引量：1
  • 2詹晓庆,王鲜忠,张家骅.雌激素受体和雌性生殖研究进展[J].动物医学进展,2005,26(12):35-39. 被引量：19
  • 3王玉,杨清.孕激素膜受体的研究进展[J].国外医学（计划生育．生殖健康分册）,2006,25(1):31-34. 被引量：3
  • 4章孝荣,王建辰.山羊GnRH和促性腺激素的释放特点[J].中国兽医学报,1997,17(2):177-179. 被引量：27
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  • 10Martensson UE, Salehi SA, Windahl S, et al. Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice. Endocrinology, 2009, 150(2): 687-98.

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生物化学与生物物理进展
2010年 第6期

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