摘要
雌激素的非基因组调节模式在雌性生殖系统中广泛存在.雌激素通过基因组、非基因组及两种调节模式的整合在不同组织中行使多种生理功能.卵巢中雌激素能通过非基因组效应对卵细胞起到保护作用.子宫中雌激素对多种基因的表达都是通过非基因组模式.对雌激素非基因组效应的研究将有利于进一步了解雌激素的作用机制.
Non-genomic effects of estrogen exist largely in female reproductive system. Through genomic and non-genomic pathways, and their integration, estrogen performs different physiological functions in various target tissues. In the ovary, estrogen functions as a reactive oxygen scavenger and protects ovarian cells from apoptosis through non-genomic pathway. Estrogen also regulates the expression of uterine genes in an estrogen receptor-independent manner. The review on estrogen non-genomic effects will be beneficial for understanding the mechanism of estrogen action.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2010年第6期594-599,共6页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金重点资助项目(30930013)~~