摘要
目的评价早期乳腺癌保乳术后调强适形放疗(IMRT)的疗效。方法计算机检索中文科技期刊全文数据库、中国期刊全文数据库、数字化期刊全文数据库、中国生物医学文献数据库、PubMed、Cochrane Library、SCI及EMBASE数据库,并辅手工检索和其他检索。纳入比较早期乳腺癌保乳术后调强适形放疗与传统放疗(RT)的随机对照试验,根据Cochrane系统评价手册5.0.0质量评价标准进行质量评价,使用RevMan5.0软件进行Meta分析。结果共纳入4个研究(1 440例)。Meta分析显示,与RT相比,IMRT可降低急性湿性皮炎、乳房浮肿和色素沉着的发生。结论IMRT可明显降低急性湿性皮炎的发生,减轻患者痛苦,提高生活质量。
Objective To assess the long-term effect of breast conservation with breast intensity-modulated radiotherapy（IMRT） for early-stage breast cancer.Methods The randomized controlled trials in PubMed,Cochrane Library（issue 3,2008）,EMBASE,SCI,Chinese Biomedical Database,Chinese Studies Online,Chinese Scientific Journals Full-text Database and China Journal Full-text Database were searched.Quality assessment and data extraction were done by two reviewers independently according to the Cochrane Reviewer′s handbook 5.0.0.Meta-analyses were performed on the results of homogenous studies by RevMan 5.0.Results Four studies（1 440 patients） were included.IMRT significantly reduced the occurrence of moist acute dermatitis,breast swelling and pigmentation.Conclusions IMRT could significantly reduce the occurrence of moist acute dermatitis,alleviate the patients′ suffering and improve the quality of life.
出处
《实用肿瘤杂志》
CAS
北大核心
2010年第3期291-295,共5页
Journal of Practical Oncology
基金
国家自然科学研究基金(096RJZA036)
卫生部项目"肿瘤精确放射治疗网络研究子课题(320.6750.06016-17-20)
重离子等射线治疗肿瘤研究科技创新团队建设计划(098TTCA009)
兰州大学循证医学中心"循证医学研究生创新基金"
关键词
乳腺肿瘤
放射疗法
适形
综合分析
随机对照研究
breast neoplasms
radiotherapy
conformal
Meta-analysis
randomized controlled trials
