计算机形态定量用于扩张型心肌病心肌活检病理诊断的探索

Investigation on Pathologic Diagnosis of Endomyocardial Biopsy of DCM by Morphometric Analysis of Computer

应用计算机彩色图像分析技术，对扩张型心肌病（ＤＣＭ）心肌活检标本的病理变化进行形态识别，提取多种参数，寻找对ＤＣＭ具有病理诊断价值的指标。选择４１例临床及病理变化符合ＤＣＭ的病例，平均年龄３８．７６ｙ。结果表明，心肌细胞直径、心肌细胞核的形态参数、胞浆疏松化、收缩带、心肌间质纤维化、心肌细胞的排列、心内膜厚度及平滑肌细胞增生密度等指标对ＤＣＭ具有重要的病理诊断价值。提示这８类指标可用来建立ＤＣＭ的数据库，研制“ＤＣＭ医学形态学识别系统”

In seeking the targets for pathological diagnosis of dilated cardiomyopathy(DCM), pathological changes of endomyocardial biopsy specimens of DCM were distinguished by colour image analysis of a computer and many parameters were obtained. Forty one cases whose clinical and pathological features fit in with DCM were selected. The average age of them was 38.76 years old. The results indicated that the eight targets(e.g. the diameter of myocardial cells, the morphological parameters of nuclei, watery appearing cytoplasm, constrictive bands, fibrosis of myocardial mesenchyme, arrangement of myocardial cells, thickness of endocardium and proliferation density of smooth muscle cells of endocardium) were of importance to pathological diagnosis of DCM. The paper suggests that the eight targets can be used to establish data bank of DCM and research in “the Medical Morphological Analysis System of DCM”.