期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

表观遗传修饰调控胚胎干细胞定向分化的研究进展 被引量：2

Progress of embryonic stem cells during directional differentiation regulated by epigenetic modification
下载PDF
导出
摘要 Embryonic stem cells undergo extensive self-renewal and have the capacity to differentiate along multiple cell lineages.Research on totipotency and directional differentiation of embryonic stem cells in order to treat intractable disease,such as cancer,heart failure,atherosclerosis by tissue regeneration and cell transplantation are investigated.Epigenetic modification,including DNA methylation,chromatin restructure,and non-coding RNA-mediated regulatory events,regulate the differentiation of embryonic stem cells without detectable genetic changes.These mechanisms are often associated with starting-up and maintenance of epigenetic silence.The achievement and focuses on the molecular mechanism of embryonic stem cells during directional differentiation regulated by epigenetic modification are reviewed. Embryonic stem cells undergo extensive self- renewal and have the capacity to differentiate along multiple cell lineages. Research on totipotency and directional differentiation of embryonic stem cells in order to treat intractable disease, such as cancer, heart failure, atherosclerosis by tissue regeneration and cell transplantation are investigated. Epigenetic modification, including DNA methylation, chromatin restructure, and non -coding RNA -mediated regulatory events, regulate the differentiation of embryonic stem cells without detectable genetic changes. These mechanisms are often associated with starting - up and maintenance of epigenetic silence. The achievement and focuses on the molecular mechanism of embryonic stem cells during directional differentiation regulated by epigenetic modification are reviewed.
作者 罗定远 黎洪浩
机构地区 中山大学附属第二医院血管外科
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2010年第6期1229-1233,共5页 Chinese Journal of Pathophysiology
关键词 表观遗传修饰 胚胎干细胞 细胞分化 Epigenetic modification Embryonic stem cells cell differentiation
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献33

  • 1Ivanova NB,Dimos JT,Schaniel C,et al.A stem cell molecular signature[J].Science,2002,298(5593):601-604.
  • 2Bird A.DNA methylation patterns and epigenetic memory[J].Genes Dev,2002,16(1):6-21.
  • 3Murrell A,Rakyan VK,Beck S.From genome to epigenome[J].Hum Mol Genet,2005,14(1):R3-R10.
  • 4Morgan HD,Santos F,Green K,et al.Epigenetic reprogramming in mammals[J].Hum Mol Genet,2005,14 (1):R47-R58.
  • 5Li JY,Pu MT,Hirasawa R,et al.Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog[J].Mol Cell Biol,2007,27(24):8748-8759.
  • 6Yoder JA,Soman NS,Verdine GL,et al.DNA (cytosine-5)-methyltransferases in mouse cells and tissues.Studies with a mechanism-based probe[J].J Mol Biol,1997,270(3):385-395.
  • 7Rhee I,Jair KW,Yen RW,et al.CpG methylation is maintained in human cancer cells lacking DNMT1[J].Nature,2000,404(6781):1003-1007.
  • 8Chen T,Hevi S,Gay F,et al.Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells[J].Nat Genet,2007,39(3):391-396.
  • 9Shen Y,Chow J,Wang Z,et al.Abnormal CpG island methylation occurs during in vitro differentiation of human embryonic stem cells[J].Hum Mol Genet,2006,15(17):2623-2635.
  • 10Lagarkova MA,Volchkov PY,Lyakisheva AV,et al.Diverse epigenetic profile of novel human embryonic stem cell lines[J].Cell Cycle,2006,5(4):416-420.

二级参考文献12

共引文献10

同被引文献42

  • 1Bhatt S,Gething PW,Brady OJ,et al.The global distribution and burden of dengue [ J ].Nature, 2013,496 (7446) : 504-507.
  • 2Wan SW,Lin CF,Yeh TM,et al.Autoimmunity in dengue pathogenesis [ J ] .J Formos Med Asso, 2013,112 ( 1 ) : 3-11.
  • 3Clark IA.The advent of the cytokine storm [J].immunol Cell Biol, 2007,85 (4) : 271-273.
  • 4Jaenisch R,Bird A.Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals [J ] .Nat Genet, 2003,33 (Suppl) : 245-254.
  • 5Costello JF, Frtihwald MC, Smiraglia DJ, et al.Aberrant CpG- island methylation has non-random and turnout-type specific patterns [J] .Nai Genet, 2000,24(2) : 132-138.
  • 6L1ave C, Kasschau KD, Recior MA, et al.Endogenous and silencing-associated small RNAs in plants [J].Plant Cell, 2002, 14(7) : 1605-1619.
  • 7Kim vN, Han J, Siomi MC.Biogenesis of small RNAs in animals [J].Nat Rev Mol Cell Biol,2009,10(2) : 126-139.
  • 8Yoda M, Kawamata T, Paroo Z, et al.ATP-dependent human RISC assembly pathways[J].Nat Struct Mol Biol, 2010,17(1) : 17-23.
  • 9Lim LP,Lau NC,Garrett-Engele P,et al.Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs [ J ] .Nature, 2005,433 (7027) : 769-773.
  • 10Lewis BP,Burge CB,Bartel DP.Conserved seed pairing,often flanked by adenosines, indicates that thousands of human genes are microRNA targets [ J ].Cell, 2005,120 ( 1 ) : 15- 20.

引证文献2

二级引证文献3

中国病理生理杂志
2010年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部