期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

碘对比剂剂量对犬血浆ET-1和CGRP的影响及意义 被引量：1

Effect of different constrast medium dose to ET-1 and CGRP in blood plasma of dogs and its significance
下载PDF
导出
摘要 目的:探讨碘对比剂剂量对犬血浆ET-1和CGRP的影响,为临床使用低剂量碘对比剂可降低毒副反应发生提供实验依据。材料和方法:家犬静脉高压(1.2ml/s)注射不同剂量(2.93ml/kg,2.20ml/kg,1.47ml/kg)碘海醇,对照组给予等量生理盐水,注射后不同时间点抽取静脉血,采用放射免疫法检测血浆ET-1和CGRP含量。结果:①高剂量组与中、低剂量组和对照组比较血浆ET-1含量明显增加,各组间均有显著性差异(P<0.01),呈量效关系;②组间比较高、中剂量组CGRP下降水平(P=0.099)无统计学差异,余各组间均有显著性差异(P<0.01);③高、中剂量组ET-1与CGRP呈显著负相关,血浆ET-1在注射对比剂后30min达峰值,CGRP在30min降至最低值。结论:血浆ET-1和CGRP含量变化与剂量有关,使用低剂量碘对比剂可降低对比剂副反应发生。
作者 钱颖 吴宗霞 雷振 王志铭
机构地区 辽宁医学院附属第一医院放射科
出处 《中国临床医学影像杂志》 CAS 北大核心 2010年第1期69-71,共3页 Journal of China Clinic Medical Imaging
关键词 碘海醇 降钙素基因相关肽 内皮缩血管肽1 狗
分类号 R814.43 [医药卫生—影像医学与核医学] R331.36 [医药卫生—人体生理学]
  • 相关文献

参考文献14

  • 1Katzberg RW,Haller C.Contrast-induced nephrotoxicity:clinical landscape[J].J Kidney Int Suppl,2006,100(4):S3-S7.
  • 2Marenzi G,Lauri G,Assanelli E,et al.Contrast-induced nephropathy in patients undergoing primary angioplasty for acute myocardial infarction[J].J Am Coll Cardiol,2004,44(9):1780-1785.
  • 3Henrik S,Thomsen HS.European Society of Urogenital Radiology guidelines on contrast media application[J].J Curr Opin Urol,2007,17(1):70-76.
  • 4Toprak O,Cirit M.Risk factors and therapy strategies for contrast-induced nephropathy[J].J Ren Fail,2006,28(5):365-381.
  • 5Rihal CS,Textor SC,Grill DE,et al.Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention[J].J Circulation,2002,105(19):2259-2264.
  • 6赵景宏,黄岚,王军平,晋军,宋耀明,陈剑飞,武晓静,周健,于世勇.高渗和低渗造影剂对大鼠肾动脉内皮功能的影响及意义[J].第三军医大学学报,2006,28(16):1713-1715. 被引量：8
  • 7Oldroyd SD,Haylor JL,Morcos SK.Bosentan,an orally active endothelin antagonist:effect on renal response to contrast media[J].Radiology,1995,196(3):661-665.
  • 8Aspelin P,Stacul F,Thomsen HS,et al.Effects of iodinated contrast media on blood and endothelium[J].J Eur Radiol,2006,16(5):1041-1049.
  • 9Zhang H,Holt CM,Malik N,et al.Effects of radiographic contrast media on proliferation and apoptosis of human vascular endothelial cells[J].Br J Radiol,2000,73(874):1034-1041.
  • 10Kalani M.The importance of endothelin-1 for microvascular dysfunction in diabetes[J].J Vasc Health Risk Manage,2008,4(5):1061-1068.

二级参考文献21

  • 1de Bono DP,Yang WD.Exposure to low concentrations of hydrogen peroxide causes delayed endothelial cell death and inhibits proliferation of surviving cells[J].Atherosclerosis,1995,114(2):235-245.
  • 2Schaeffer C,Vandroux D,Thomassin L,et al.Calcitonin gene-related peptide partly protects cultured smooth muscle cells from apoptosis induced by an oxidative stress via activation of ERK1/2 MAPK[J].Biochem Biophys Acta,2003,1643(1-3):65-73.
  • 3Klein R.Hyperglycemia and microvascular and macrovascular diease in diabetes[J].Diabetes Care,1995,18(2):258-268.
  • 4Du XL,Sui GZ,Stockklauser-Farber K,et al.Introduction of apoptosis by high proinsulin and glucose in cultured human umbilical vein endothelial cells is mediated by reactive oxygen species[J].Diabetologia,1998,41(3):249-256.
  • 5Baumgartner-Parzer SM,Wagner L,Petterman M,et al.High glucose-triggered apoptosis in cultured endothelial cells[J].Diabetes,1995,44(11):1323-1327.
  • 6Mizutani M,Kern TS,Lorenzi M.Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy[J].J Clin Invest,1996,97(12):2883-2890.
  • 7Wang JH,Redmond HP,Watson RW,et al.Induction of human endothelial cell apoptosis requires both heat shock and oxidative stress responses[J].Am J Physiol,1997,272(5 pt1):1543-1551.
  • 8Bombeli T,Karsan A,Tait JF,et al.Apoptotic vascular endothelial cells become procoagulant[J].Blood,1997,89(7):2429-2442.
  • 9Scheid MP,Schubert KM,Duronio V.Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase[J].J Biol chem,1999,274(43):31108-31113.
  • 10Boucher MJ,Morisset J,Vachon PH,et al.MEK/ERK signaling pathway regulates the expression of Bcl-2,Bcl-X(L),and Mcl-1 and promotes survival of human pancreatic cancer cells[J].J Cell Biochem,2000,79(3):355-369.

共引文献18

同被引文献8

引证文献1

二级引证文献9

中国临床医学影像杂志
2010年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部