摘要
microRNA(miRNA)是一段长度约22nt的内源性非编码单链RNA分子,能在转录后水平调控基因的表达。研究证实,miRNA在细胞增殖、发育、分化、凋亡、代谢、信号转导以及肿瘤发生中发挥重要的调节作用。近年来,miRNA已经被证实能够抑制癌基因或抑癌基因的表达,参与了胃肠道肿瘤的发生和发展。本文就miRNA在人胃肠道肿瘤中的作用作一综述。
MicroRNAs （miRNAs） are endogenous, non-coding, single-strand RNA molecules with a length of about 22-nucleotides （nt）. They have post-transcriptional control of the expression of various target genes. Previous research confirmed that miRNAs play an important role in regulating cell proliferation, development, differentiation, apoptosis, metabolism and signal transduction, as well as oncogenesis. Research also confirmed that miRNAs could inhibit the expression of oncogenes or anti-oncogenes, and could take part in the tumorigenesis and progression of gastrointestinal cancers. In our paper, the effect of miRNAs in human gastrointestinal cancers is summarized.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2010年第11期656-659,共4页
Chinese Journal of Clinical Oncology
关键词
微小RNA
胃肠道癌
幽门螺杆菌
miRNA
gastrointestinal cancer
Helicobacter pylori
