阻塞性睡眠呼吸暂停与夜间多尿症状的关系

The Relationship between Obstructive Sleep Apnea and Nocturnal Diuresis

评价阻塞性睡眠呼吸暂停综合征（ＯＳＡＳ）与夜间多尿症状的关系。采用病例－对照研究方法研究６１例ＯＳＡＳ与４７例对照组、９例ＯＳＡＳ持续气道正压（ＣＰＡＰ）患者治疗前后夜间多尿症状的变化，及部分ＯＳＡＳ和对照者的夜尿量比较。结果：ＯＳＡＳ患者夜尿次数显著增多（χ２＝３３．６２，Ｐ＜０．０１），其发生夜间多尿症状的危险性是对照组的１２．９倍（ＯＲ＝１２．９，９５％可信区间为５．４～３０．６）；ＯＳＡＳ患者夜尿量明显增多（ｔ＝５．８３，Ｐ＜０．０１）；ＣＰＡＰ患者治疗后夜间多尿症状明显好转（Ｐ＝０．００１）。结论：夜间多尿症状与ＯＳＡＳ患者的睡眠呼吸暂停有关，ＣＰＡＰ治疗可改善之。

An evaluation was made to compare the effects of the treatment of post CPAP (continuous positive airway pressure) vs the treatment of pre CPAP on nocturnal diuresis in patients with obstructive sleep apnea syndrome (OSAS), in 61 patients with OSAS (males 55, females 6) vs 47 controls. Meanwhile, urinary volumes of some randomly selected patients with OSAS and controls were measured. The results showed: (1) Nocturnal diuresis was seen in patients with OSAS (χ 2=33.62, P <0.01); (2) The urinary volumes of 13 patients with OSAS in nighttime were more than that of controls ( t =5.83, P <0.01); (3)The treatment of CPAP lessened the nocturnal diuresis ( P =0.001). It suggested that nocturnal diuresis is a complication of OSAS, and the treatment of CPAP is efficacious.