多巴胺D_2受体调控睡眠-觉醒研究进展

Progress in sleep-wake regulation of dopamine D_2 receptor

脑内多巴胺(dopamine,DA)参与觉醒相关的运动、认知和奖赏等行为调控。DA能神经元主要位于黑质致密部和腹侧被盖区。DA受体(receptor,R)包括:D_1R、D_2 R(D_(2S)和D_(2L))、D_3 R、D_4R和D_5R五种亚型。中枢神经内D_1R和D_2R数目占绝对优势,D_2R对内源性DA的亲和力显著高于D_1R。近年来,药理学和基因剔除动物等研究发现:D_2R是维持觉醒的重要受体,本文综述其研究进展。

Dopamine（DA） modulates diverse wake-related behaviors including movement,reward, and cognition.Dopaminergic neurons are located in the substantia nigra pars compacta and ventral tegmental area.There are five distinct DA receptors（R）：D1R,D2R（D2SR and D2LR）, D3R,D4R and D5R in the central nervous system, in which D1R and D2R are majorly expressed. The affinity of D2R for endogenous DA is significantly higher than that of D1R.Recently,studies by pharmacological and gene knock-out animals revealed that dopamine D2R is essential inmaintaining wakefulness.Here,we review the progress on roles of D2R in sleep-wake regulation.