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有机阴离子转运多肽1A2对药物转运的影响 被引量：1

Effect on drug transport of OATP1A2
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摘要 有机阴离子转运多肽1A2(OATP1A2)是人体内重要的膜转运蛋白,在肝、肾、小肠、血脑屏障等组织部位进行表达,介导内、外源物质的跨细胞转运,对药物的吸收、分布和消除起着十分重要的作用。本文将对OATP1A2的组织分布和基本功能、基因多态性及其对药物转运的影响作一综述。 Organic anion transporting polypeptide 1A2（OATP1A2）,expressed in liver, kidney,small intestine,blood-brain barrier and other organizations,is an important membrane transporter in humans.OATP1A2 mediates the trans-membrane transport of endogenous and exogenous materials,and plays a significant role in drug absorption,distribution and elimination. This review aimes to summarize the distribution, basic functions and gene polymorphism of OATP1A2,and its impact on drug transport.
作者 彭丹 夏春华 熊玉卿
机构地区 南昌大学医学院临床药理研究所
出处 《中国临床药理学与治疗学》 CAS CSCD 2010年第4期464-469,共6页 Chinese Journal of Clinical Pharmacology and Therapeutics
关键词 有机阴离子转运多肽1A2 药物转运 药代动力学 Organic anion transporting polypeptide 1A2 Drug transport Pharmacokinetics
分类号 R969 [医药卫生—药理学]
  • 相关文献

参考文献31

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二级参考文献55

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共引文献39

同被引文献13

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引证文献1

中国临床药理学与治疗学
2010年 第4期

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